Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome
- Conditions
- Down SyndromePhysical Inactivity
- Interventions
- Behavioral: Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program
- Registration Number
- NCT06537648
- Lead Sponsor
- University of Kansas Medical Center
- Brief Summary
The investigators are assessing acceptability, appropriateness, and feasibility of an remote choreographed exercise intervention using validated scales alongside qualitative data among young adults with Down Syndrome. Participants will take part in a 12-week exercise program with two 35-minute session per week delivered in a group setting. The aims of the project are to:
* Assess the feasibility of a 12 week remotely delivered group dance intervention.
* Assess changes in aerobic fitness and cognitive function in response to a 12 week remotely delivered group dance intervention.
* Assess the intensity and total energy expenditure of remotely delivered group dance sessions.
- Detailed Description
The incidence of Alzheimer's disease for persons with Down syndrome exceeds 90%, and physical activity engagement has demonstrated potential to delay onset of Alzheimer's disease for this population. Adults with Down syndrome participate in less physical activity than their counterparts without disability, partially due to unique barriers preventing engagement in typical modalities of physical activity for this population. Dance, which is characterized by rhythmic physical movements offers the potential for social engagement, and stimulation of brain functions may offer a reasonable alternative to traditional physical activity modalities. However, empirical evidence to support the feasibility of a remotely delivered group dance intervention and evaluation of the intensity and energy expenditure achieved by a dance intervention for adults with Down syndrome are currently unavailable and will be the focus of the proposed pilot trial. Adults with Down will be asked to attend 35 minute remotely delivered (Zoom®) group dance sessions twice weekly across 12 weeks to assess the acceptability, appropriateness, and feasibility of the intervention, energy expenditure achieved during the exercise sessions, and evaluate change in aerobic fitness and cognitive function after 12 weeks.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Diagnosis of Down syndrome
- Sufficient functional ability to communicate through spoken language
- No plans to relocate outside the study area over the next 12 weeks
- Possession of a personal device that allows for connectivity to the internet and participate in 2x weekly group video calls
- Ability to participate in Moderate to vigorous physical activity
- Serious medical risk (e.g., cancer, recent heart attack, stroke, pregnancy, angioplasty as determined by the research staff
- unwilling to participate in outcomes assessments
- uninterested
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program Participants will be asked to play attend 35 minute, remotely delivered, group exercise classes using choreographed exercise twice a week for 12 weeks.
- Primary Outcome Measures
Name Time Method Attendance 12 weeks Attendance at each 35-minute online exercise classes will be collected. Attendance will be assessed as the number of sessions attended out of the total number of sessions available (24 sessions available).
Retention 12 weeks Participant retention will be collected based on the number of participants who complete the 12 week intervention. A total of up to 20 participants will be enrolled into the study. Participants that complete the 12-week intervention will be considered retained. Any participant that discontinues participation prior to the end of the 12-week intervention will not be considered retained.
Adverse Events 12 weeks Adverse events will be collected on a weekly basis.
- Secondary Outcome Measures
Name Time Method Episodic Memory 12 weeks Episodic memory will be assessed before and after the intervention using the modified Cued Recall Test.
6-minute walk test 12 weeks This test measures the distance that a participant can walk on a flat, hard surface in a period of 6 minutes. The research team will instruct them on how to prepare and conduct this test.
Energy Expenditure 1 session Energy expenditure during a dance session (kilocalories per minute; Metabolic equivalents (METs) will be assessed by portable indirect calorimetry.
Exercise intensity 12 weeks Exercise intensity will be assessed as an average of the percent of age-estimated maximal heart rate achieved during dance sessions assessed by a Fitbit®
Trial Locations
- Locations (1)
University Of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States