The effect of restricted fluid therapy on posoperative renal and pulmonary complications following liver transplantation.
Not Applicable
Completed
- Conditions
- iver Transplantation.Surgical operation with transplant of whole organ
- Registration Number
- IRCT2013101811662N4
- Lead Sponsor
- Vice-Chancellery of Research and Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 63
Inclusion Criteria
Eligible participants are all adult patients with end-stage liver who will candidate for liver transplantation.
Exclusion criteria: The patients with history of Asthma; chronic obstructive lung disease; hepatopulmonary syndrome; hepatopulmonary hypertension; hepatorenal syndrome; renal failure.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidece of acute renal failure. Timepoint: 1st day postoperation, 2nd day post operation, 3rd day postoperation. Method of measurement: Acute renal failure is define according to serum creatinine.;Incidence of acute respiratory failure. Timepoint: 1st day postoperation, 2nd day post operation, 3rd day postoperation. Method of measurement: By doiing arterial blood gas.
- Secondary Outcome Measures
Name Time Method Heart rate. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By electrocardiogram.;Mean arterial blood pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By arterial catheter in radial artery(mmHg).;Cardiac output. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By NICO system for measuring noninvasive CO.;Central venous pressure. Timepoint: 30 minutes after surgical incision,at start of anhepatic phase,at start of neohepatic phase. Method of measurement: By internal jagular catheter.
Related Research Topics
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What molecular mechanisms link restricted crystalloid fluid therapy to reduced postoperative renal insufficiency after liver transplantation?
How does restricted fluid therapy compare to standard fluid management in preventing pulmonary complications following liver transplant surgery?
Are there specific biomarkers that identify patients who benefit most from restricted fluid therapy during liver transplantation?
What adverse events are associated with restricted crystalloid fluid administration in liver transplant recipients and how are they managed?
What is the role of fluid restriction in optimizing graft function and minimizing organ edema in liver transplant patients compared to other perioperative strategies?