General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- The changes of peripheral immune cells and cytokines
研究概览
简要总结
The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 51 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with Colorectal Cancer(CRC);
- •subjected to the Fast-Track processing of surgery;
- •between 18 and 75 years old.
排除标准
- •American Society of Anesthesiologists(ASA) grade > III;
- •BMI > 30;
- •a history of abdominal surgery, endocrine or immune system dysfunction;
- •recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
- •previous contraindication to epidural anesthesia.
研究组 & 干预措施
general anesthesia & epidural anesthesia
26 patients received general anesthesia combined with epidural anesthesia for surgery, and patient-controlled epidural analgesia for 2 days after surgery
干预措施: epidural anesthesia (Procedure)
general anesthesia & epidural anesthesia
26 patients received general anesthesia combined with epidural anesthesia for surgery, and patient-controlled epidural analgesia for 2 days after surgery
干预措施: general anesthesia (Procedure)
general anesthesia
27 patients received general anesthesia for surgery, and patient-controlled intravenous analgesia for 2 days after surgery
干预措施: general anesthesia (Procedure)
结局指标
主要结局
The changes of peripheral immune cells and cytokines
时间窗: within the first 5 days after surgery
The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines
次要结局
未报告次要终点
研究者
Changhong Miao
Professor, Department of Anesthesiology
Fudan University