Fragmentation of Elastin as a Biological Marker of Frailty and Impact in Tumor Progression in Elderly Patients With Cancer

Not Applicable

Completed

• Conditions: Cancer
• Interventions: Biological: blood withdrawn; Biological: urine collection

• Registration Number: NCT02807129
• Lead Sponsor: CHU de Reims

Brief Summary

The aim of the study is to evaluate frailty in patients aged ≥ 65 years with cancer. The elderly population is very heterogeneous, it is necessary to evaluate these elderly patients before treatment to assess the risk-benefit balance. To date, this assessment relies on subjective clinical methods often not optimal, and slow to implement. An innovative method of evaluation could be the determination of elastin peptides. Indeed, the rate of these peptides, which are linked to serious conditions associated with age, rising inexorably with age and dose could help determine more objectively the type of treatment to offer older patients.

Expected results : This study will allow better identification of the group of frail elderly through more relevant biological marker that clinical assessment, often subjective and not available within a period compatible with the treatment of newly diagnosed cancer. This biological assessment will also enable optimal management of elderly patients in particular by allowing the geriatrician better efficiency.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-29
• Study First Submitted: 2016-06-16
• Study First Submitted QC: 2016-06-20
• Study First Posted: 2016-06-21
• Primary Completion: 2023-01-16
• Study Completion: 2023-01-16
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-27
• Last Update Posted: 2025-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 296

Inclusion Criteria

• 65 years or older
• diagnosis of cancer
• affiliation to a social security scheme
• Signed informed consent for the study and for the collection of biological samples

Exclusion Criteria

• Patient protected by law (guardianship, trusteeship)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
patients	blood withdrawn	-
patients	urine collection	-

Primary Outcome Measures

Name	Time	Method
elastin peptides quantification	up to 36 months

Trial Locations

Locations (1)

Damien JOLLY; 🇫🇷 Reims, France