Diagnosis and Treatment of Non-communicable Diseases and Geriatric Syndromes in the HIV Aging Population in Sub-Saharan Africa
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Makerere University
- Enrollment
- 500
- Primary Endpoint
- Change in proportion of participants with any non communicable disease
Study Overview
Brief Summary
The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in sub-Saharan Africa
Detailed Description
The establishment and scale up of solid and sustainable HIV programs in sub-Saharan Africa (SSA) has led to a reduction in mortality and morbidity from HIV related opportunistic infections and some HIV related cancers. This improved survival has resulted in two phenomena: the first is the surfacing of non-communicable diseases (NCDs) in the HIV population, especially in those on long-term ART, and the second is increased longevity leading to increasing numbers of elderly HIV infected individuals
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 60 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 60 years and above
- •Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study.
- •Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
Exclusion Criteria
- •Any clinical (physical and psychiatric) condition which prevents the patients to participate safely in the study procedures according to the judgments of a physician.
- •Subjects already enrolled in experimental clinical trial.
Outcomes
Primary Outcomes
Change in proportion of participants with any non communicable disease
Time Frame: Enrollment, year 1, year 2
Proportion with any non communicable disease (including hypertension, cardio vascular disease, respiratory disease, renal disease, non HIV related cancers, frailty)
Change in Quality of life
Time Frame: Enrollment, year 1, year 2
Quality of life measured using the WHO Quality of life for elderly (WHOQOL-OLD)
Secondary Outcomes
- Change in proportion of patients with polypharmacy monitoring(Enrollment, year 1, year 2)
- Change in Nutritional status assessed by Mini Nutritional Assessments (MNA)(Enrollment, year 1, year 2)
- Change in proportion of patients with disability(Enrollment, year 1, year 2)
- Change in proportion of patients with history of falls(Enrollment, year 1, year 2)
- Change in proportion of patients with urinary incontinence measured by ICIQ-UI Short(Enrollment, year 1, year 2)
- Change in proportion of patients with depression(Enrollment, year 1, year 2)
- Change in proportion of patients with cognitive deficit(Enrollment, year 1, year 2)