Antibiotic Regimens Tailored by Clinical Pharmacist Suppored by Intensivist Enhanced Rational Use of Antibiotics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critical Illness
- Sponsor
- University of Alexandria
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Antibiotics consumption
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
adding pharmaceutical services to patient care and changing the professional activity of pharmacists from drug-focused to patient-oriented care,in the current study, clinical pharmacists will be assigned to monitor pharmacotherapy regimens, participate in patient care, and cooperate in educating the staff and evaluating care.
Detailed Description
During the intervention period, the pharmacist attended daily unit rounds with ICU intensivist with a focus on optimization of antibiotic regimens. Pharmacist consultative services were also available by phone calls 24 hours x 7 days if needed. For every patient surgical prophylactic antibiotic initiated immediately before surgery and continued for 48 hours following surgery. Antibiotic therapy had given as either directed or empiric. Directed therapy was defined as treatment of a documented infection based on culture and sensitivity. Empiric therapy was defined as any antibiotic therapy administered when no documented infection was present, and the patient had clinically suspected infection following surgery. Empiric antibiotic administration was required in majority of our SICU patients. Antibiotics had given after exclusion of allergy by history and intradermal sensitivity test.
Investigators
Ibrahim Mabrouk Ibrahim
lecturer in the anaesthesia department Alexandria university
University of Alexandria
Eligibility Criteria
Inclusion Criteria
- •all admitted patients to the ICU between age 18-80 years old
Exclusion Criteria
- •Patient admitted for less than 24 hours (including deaths and transfers) will be excluded from the study.
- •Pediatric patients weighted less than kilograms.
Outcomes
Primary Outcomes
Antibiotics consumption
Time Frame: 1 year
consumption will be counted as number of defined daily doses (DDD), expressed as DDD per 100 patient-days
Average length of stay
Time Frame: 1 year
the average number of days that patients spent in SICU.
Mortality rate
Time Frame: 1 year
The number of deaths of patients admitted to SICU, divided by the number of admissions.