Antibiotic Regimens Tailored by Clinical Pharmacist Suppored by Intensivist Enhanced Rational Use of Antibiotics

Completed

• Conditions: Critical Illness
• Interventions: Other: Clinical pharmacy sharing in the patient care regimen

• Registration Number: NCT04931914
• Lead Sponsor: University of Alexandria

Brief Summary

adding pharmaceutical services to patient care and changing the professional activity of pharmacists from drug-focused to patient-oriented care,in the current study, clinical pharmacists will be assigned to monitor pharmacotherapy regimens, participate in patient care, and cooperate in educating the staff and evaluating care.

Detailed Description

During the intervention period, the pharmacist attended daily unit rounds with ICU intensivist with a focus on optimization of antibiotic regimens. Pharmacist consultative services were also available by phone calls 24 hours x 7 days if needed. For every patient surgical prophylactic antibiotic initiated immediately before surgery and continued for 48 hours following surgery. Antibiotic therapy had given as either directed or empiric. Directed therapy was defined as treatment of a documented infection based on culture and sensitivity. Empiric therapy was defined as any antibiotic therapy administered when no documented infection was present, and the patient had clinically suspected infection following surgery. Empiric antibiotic administration was required in majority of our SICU patients. Antibiotics had given after exclusion of allergy by history and intradermal sensitivity test.

Study Timeline

• Study Start: 2020-01-04
• Primary Completion: 2020-12-05
• Study Completion: 2020-12-25
• Study First Submitted: 2021-05-29
• Study First Submitted QC: 2021-06-08
• Study First Posted: 2021-06-18
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-05
• Last Update Posted: 2022-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• all admitted patients to the ICU between age 18-80 years old

Exclusion Criteria

• Patient admitted for less than 24 hours (including deaths and transfers) will be excluded from the study.

Pediatric patients weighted less than kilograms.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group c	Clinical pharmacy sharing in the patient care regimen	Patients admitted from June 9, 2020 to june 31, 2021.

Primary Outcome Measures

Name	Time	Method
Antibiotics consumption	1 year	consumption will be counted as number of defined daily doses (DDD), expressed as DDD per 100 patient-days
Average length of stay	1 year	the average number of days that patients spent in SICU.
Mortality rate	1 year	The number of deaths of patients admitted to SICU, divided by the number of admissions.

Trial Locations

Locations (1)

Alexandria university; 🇪🇬 Alexandria, Egypt