Evaluation of an Enriched Speech Rehabilitation Program Combining Speech Therapy and Sensory-motor Integration in Aphasic Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Evaluation of acoustic changes in the speech signal before and after each rehabilitation protocol
研究概览
简要总结
SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.
详细描述
In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with non-fluent aphasia after lesion in the dominant hemisphere for language
- •native speakers of French
- •normal or corrected to normal vision
- •satisfying all criteria for the MRI examination
排除标准
- •patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia
结局指标
主要结局
Evaluation of acoustic changes in the speech signal before and after each rehabilitation protocol
时间窗: Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention
Assessment of acoustic properties (formants, voice onset time and spectral moments) with a phoneme repetition task. Repeated phonemes are isolated vowels, semi-consonants in vowel context and consonants in /a/ context with the consonants (C) placed in initial (/Ca/) or medial (/aCa/) positions.
次要结局
- Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 1(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 2(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Clinical language assessment 1a(Baseline pre-intervention)
- Evaluation of changes in language abilities before and after rehabilitation - Clinical language assessment 1b(Immediately after the first intervention; immediately after the second intervention)
- Clinical language assessment 2a(Baseline pre-intervention)
- Evaluation of changes in language abilities before and after rehabilitation - Clinical language assessment 2b(Immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 3(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Clinical language assessment 4(Baseline pre-intervention)
- Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 5(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 6(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in cognitive level before and after each rehabilitation protocol - Neuropsychological assessment 1(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 2(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 3(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 4(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in non-verbal episodic memory before and after each rehabilitation protocol - Neuropsychological assessment 5(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of changes in mental rotation abilities before and after each rehabilitation protocol - Neuropsychological assessment 6(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of mood changes before and after each rehabilitation protocol - Neuropsychological assessment 7(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Evaluation of mood changes before and after each rehabilitation protocol - Neuropsychological assessment 8(Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention)
- Neuropsychological assessment 9(Baseline pre-intervention)
- Evaluation of brain network activation (with measurement of BOLD, Blood Oxygen Level Dependent) before and after rehabilitation - Evaluation-brain 1(Baseline pre-intervention; immediately after the first intervention)
- Evaluation of brain functional connectivity before and after rehabilitation - Evaluation-brain 2(Baseline pre-intervention; immediately after the first intervention)
- Evaluation of brain anatomical connectivity before and after rehabilitation - Evaluation-brain 3(Baseline pre-intervention; immediately after the first intervention)