The Effect of High-Velocity Low-Amplitude Thrust Manipulation of the Cervical Spine on Pain Biomarkers in Females With Non-Specific Mechanical Neck Pain
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Loma Linda University
- Enrollment
- 28
- Locations
- 2
- Primary Endpoint
- Plasma Concentration of Oxytocin
Study Overview
Brief Summary
This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and cortisol; and Examine the effect of HVLAT manipulation on pain perception in symptomatic females with non-specific mechanical cervical spine pain
Detailed Description
A high-velocity low-amplitude thrust (HVLAT) manipulation or commonly known as a spinal manipulation, is an intervention frequently used by physical therapists and other healthcare practitioners as an alternative treatment to help relieve spinal pain The mechanism by which HVLAT manipulation modulates pain remains undefined, although this does not contradict the clinical effects from HVLAT manipulation. Furthermore, there is evidence that suggests analgesia after HVLAT manipulation. There is a variety of observed and proposed phenomena that can explain the mechanisms for the psychological, mechanical, or neurophysiological responses from a HVLAT manipulation associated with alterations in pain processing or sympathetic and motor systems' excitation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 20 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •20 - 45 years of age
- •A score of 10 or more out of 50 on the Neck Disability Index (NDI) questionnaire
- •Symptoms of pain present for 30 days or less and no pain symptoms below your shoulder
Exclusion Criteria
- •Serious condition (such as cancer, spondylolisthesis, rheumatoid arthritis, or ankylosing spondylitis)
- •Cervical spinal stenosis signs (such as incoordination in hands, arms and legs, inability of walking at a brisk pace, or bowel and bladder incontinence)
- •Nerve root compression (such as changes in sensation, muscle weakness, or decreased reflexes)
- •Works the night shift
- •Steroid medication within 3 months
- •Pregnancy or postpartum
- •Pending legal action regarding their neck pain
- •History of whiplash associated disorder and/or cervical spine surgery
Outcomes
Primary Outcomes
Plasma Concentration of Oxytocin
Time Frame: Blood will be drawn immediately after HVLAT procedure.
Samples were analyzed for Human Oxytocin, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).
Secondary Outcomes
- Plasma Concentration of Neurotensin(Blood will be drawn immediately after HVLAT procedure.)
- Plasma Concentration of Cortisol(Blood will be drawn immediately after HVLAT procedure.)
- Plasma Concentration of Orexin A(Blood will be drawn immediately after HVLAT procedure.)
Investigators
Everett Lohman
D.Sc., P.T., OCS Professor Allied Health.
Loma Linda University