Nanoparticles in Blood: Understanding and Controlling Protein Corona for Optimized Nanomedicine
Not yet recruiting
- Conditions
- Coagulation Tests
- Interventions
- Other: blood tests
- Registration Number
- NCT05690542
- Lead Sponsor
- Centre Hospitalier Universitaire Dijon
- Brief Summary
The main objective is to study the effect of engineered nanoparticles SPIONs (superparamagnetic iron oxide) on hemostasis. Nanoparticles will be incubated in blood and platelet aggregation will be measured. In parallel, nanoparticles will also be incubated in blood and then plasma proteins adsorbed on them will be separated and analyzed. The proteins found on the nanoparticles will be linked to the platelet aggregation observed to help developing innovative protein functionalized nanoprobes for optimized nanomedicine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- all people
Exclusion Criteria
- patient under 18 years old, legal protection measure, pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description controls blood tests healthy people patients from intensive care units blood tests patients with hemostasis disorders (coagulation and/or platelets), antiplatelet and/or anticoagulant treatment
- Primary Outcome Measures
Name Time Method impact of nanoparticles on coagulation tests ou platelet functions at the baseline
- Secondary Outcome Measures
Name Time Method Difference of behaviour of the nanoparticles (N=10 preparations) on coagulation cascade and platelet functions at the baseline
Trial Locations
- Locations (1)
CHU DIJON BOURGOGNE - laboratoire mixte
🇫🇷Dijon, France