Nanoparticles in Blood: Understanding and Controlling Protein Corona for Optimized Nanomedicine

Not yet recruiting

• Conditions: Coagulation Tests

• Registration Number: NCT05690542
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

The main objective is to study the effect of engineered nanoparticles SPIONs (superparamagnetic iron oxide) on hemostasis. Nanoparticles will be incubated in blood and platelet aggregation will be measured. In parallel, nanoparticles will also be incubated in blood and then plasma proteins adsorbed on them will be separated and analyzed. The proteins found on the nanoparticles will be linked to the platelet aggregation observed to help developing innovative protein functionalized nanoprobes for optimized nanomedicine.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-01
• Study First Submitted: 2023-01-10
• Study First Submitted QC: 2023-01-10
• Last Update Submitted: 2023-01-10
• Study First Posted: 2023-01-19
• Last Update Posted: 2023-01-19
• Study Start: 2023-02
• Primary Completion: 2024-01
• Study Completion: 2024-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• all people

Exclusion Criteria

• patient under 18 years old, legal protection measure, pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
impact of nanoparticles on coagulation tests ou platelet functions	at the baseline

Secondary Outcome Measures

Name	Time	Method
Difference of behaviour of the nanoparticles (N=10 preparations) on coagulation cascade and platelet functions	at the baseline

Trial Locations

Locations (1)

CHU DIJON BOURGOGNE - laboratoire mixte; 🇫🇷 Dijon, France