FILIP: Fat Intake, Inflammation and LIPids
- Conditions
- Cardiometabolic Risk FactorsInflammationMicrobiota
- Registration Number
- NCT06640036
- Lead Sponsor
- Göteborg University
- Brief Summary
Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process. How nutritional composition of the diet affects the inflammatory response is however not well understood.
The aim of this project is to study if intake of three different fat sources induce different effects on inflammation markers, blood lipids, blood glucose and the microbiota.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 25
- Age 18-60
- Willing to eat the study diet
- malabsorption-related condition
- contraindications to consume a high fat diet
- intolerance to any foods used in the study (e.g. cow's milk, egg, gluten)
- established cardiovascular disease, diabetes or cancer
- current use of medication known to affect lipid metabolism (e.g. statins) or inflammation (e.g. NSAID, glucocorticoids).
- hemoglobin <100 g/L
- ongoing pregnancy or lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Total cholesterol Baseline and 1 week hs-CRP Baseline and 1 week High sensitivity C-reactive Protein
- Secondary Outcome Measures
Name Time Method Inflammation markers Baseline and 1 week Eg. GlycA, IL6, TNF-a
Blood lipid propfile Baseline and 1 week Blood lipids and their subfractions, lipoproteins, apolipoproteins
Glucose Continuous during 1 week Glucose, measured by continuous blood glucose monitoring
Microbiota Baseline and 1 week Change in gut microbial composition and diversity (alpha- and beta).
Trial Locations
- Locations (1)
University of Gothenburg
🇸🇪Gothenburg, Sweden