HUTT to Assess Cardiac Autonomic Nervous Function

Not yet recruiting

• Conditions: Autonomic Nervous System Diseases

• Registration Number: NCT06236945
• Lead Sponsor: The First Hospital of Hebei Medical University

Brief Summary

Autonomic nervous system diseases can cause abnormalities in the circulatory system, leading to malignant arrhythmia and sudden cardiac death. Standardized, operable, and simplified diagnostic indicators are urgently needed to evaluate autonomic nervous function, particularly cardiac autonomic nervous function. The investigators use HUTT in order to provide data support for cardiac autonomic nervous system evaluation.

Detailed Description

In this study, 169 samples with vertical tilt test and 24-h Holter ECG data from February 13, 2023 to October 31, 2023 were selected. The AC, DC, and 24-h HRV were compared with the CASS to identify the indicators with the strongest correlation with the CASS sympathetic and vagus nerve scores. The best index was selected, and the score intervals were delimited. The sensitivity and specificity of the defined vagal and sympathetic intervals were analyzed.

Study Timeline

• Status Verified: 2023-12
• Study First Submitted: 2023-12-27
• Study First Submitted QC: 2024-01-24
• Last Update Submitted: 2024-01-24
• Study Start: 2024-01-31
• Study First Posted: 2024-02-01
• Last Update Posted: 2024-02-01
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 169

Inclusion Criteria

• Vertical tilt test and 24-hour holter electrocardiogram were performed at the same time

  • Receive treatment in our hospital.

Exclusion Criteria

• Taking benzodiazepines or hypotensive drugs within 24 hours

  • Combined with mental illness, severe dementia, serious organ disease

    • Severe arrhythmia, deep breathing and poor coordination of Valsaval movements affected the interpretation of results.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To find the indicators which are most correlated to the sympathetic and vagus nerves.	February 13, 2023 to December 31, 2025	The investigators use HUTT and CASS score to find some indicators which are most correlated to the sympathetic and vagus nerves,so that can give data support to the clinical treatments

Trial Locations

Locations (1)

The First Hospital Of Hebei Medical University; 🇨🇳 Shijiazhuang, Hebei, China