NL-OMON45361RecruitingNot Applicable
Visual Snow: Studying the visual snow phenotype and shared mechanisms with migraine pathophysiology - SNOW Study
eurologie0 sites250 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 250
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 64 (—)
Inclusion Criteria
- •* Age *18 years (and <50 for those participating in MRS)
- •* Ability and willingness to provide written informed consent;Visual snow syndrome
- •* Visual disturbances suggestive of visual snow (for detailed clinical description)
- •* Clinical diagnosis of the visual snow syndrome (for case-control measurements);HPPD
- •* Continuous visual disturbances that started after drug intoxication (for detailed clinical description)
- •* Clinical diagnosis of visual snow starting after drug use (for case-control measurements) ;Migraine patients with frequent auras
- •* Meeting diagnostic criteria for migraine with aura (ICHD-III beta)
- •* At least one visual migraine aura per month (average of the past 6 months)
- •* For clinical description patients with atypical visual auras (visual symptoms mimicking visual snow description, visual auras longer than 1 hour) can also be included. For case-control measurement we aim for a homogenous study group and atypical auras are therefore excluded.;Tinnitus
- •* Daily complaints of tinnitus;Healthy controls
- •* See exclusion criteria
Exclusion Criteria
- •General exclusion criteria for those willing to participate in case-control measurements
- •* Subjects who do not want to be informed about unexpected findings that are considered serious and have prognostic or therapeutic consequences
- •* Schizophrenia, bipolar disorder, other psychotic disorders in medical history or current clinical suspicion of psychosis (delusions)
- •* Malignancy in medical history
- •* Central nervous system disease in medical history (other than migraine)
- •* For those participating in MRS: Pacemaker or ICD, Metal implants which cannot be removed, Pregnancy, Claustrophobia;Visual snow
- •* Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1)) ;HPPD
- •* Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1))
- •* Clinical suspicion that visual symptoms are part of psychosis, delirium, neurodegenerative disease or hypnopompic hallucinations ;Migraine patients with frequent auras
- •* Meeting criteria for any other (comorbid) headache disorder except for tension type headache
- •* Clinical suspicion that patient has Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; often presents with frequent auras) or any other hereditary cerebral amyloid angiopathy
- •* (History of) ophthalmological disease other than refraction error
- •* (History of) chronic tinnitus;Tinnitus patients
- •* Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache
- •* (History of) ophthalmological disease other than refraction error;Healthy controls
- •* Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache
- •* (History of) ophthalmological disease other than refraction error
- •* (History of) chronic tinnitus
Investigators
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