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临床试验/NCT01292395
NCT01292395已完成不适用

The Musculoskeletal Response to Energy Deficit: Defining Optimal Protein Intake

United States Army Research Institute of Environmental Medicine2 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2010年9月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
42
试验地点
2
主要终点
Change from weight maintenance in muscle metabolism after energy restriction

研究概览

简要总结

Military personnel face many physiological challenges, including sustained physical activity and prolonged periods of negative energy balance. Chronic energy deficiency often results in a loss of skeletal muscle mass and can reduce overall bone health. Recent evidence suggests that dietary interventions that provide protein in excess of the current national dietary recommendation may confer protection against the negative effects of energy deficiency on the musculoskeletal system. The primary objective of this randomized, controlled study is to assess the effects dietary protein intake spanning the current acceptable macronutrient distribution range on musculoskeletal health following prolonged energy deficiency. Findings from this investigation will improve current understanding of dietary conditions necessary to reduce the damaging effects of caloric deficiency on musculoskeletal health in warfighters. Furthermore, given the rise in obesity in military populations, findings may aid in the development of nutritional weight management strategies that promote healthy weight loss without compromising musculoskeletal health.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 42 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Weight stable with body mass index 22-29 kg/m2
  • Physically active
  • Refrain from NSAIDS and other aspirin containing medications
  • Refrain from alcohol and nicotine

排除标准

  • Metabolic or cardiovascular abnormalities, gastrointestinal disorders
  • Disease or medication that affects metabolism and/or exercise
  • Allergies or intolerance to foods, vegetarian practices, or medications to be used in the study
  • Anemia and Sickle Cell Anemia/Trait; abnormal PT/PTT test or problems with blood clotting
  • Present condition of alcoholism, use of nutritional/sports supplements, anabolic steroids, or other substance abuse issues
  • Musculoskeletal injuries that compromise the ability to exercise
  • Blood donation within 8 weeks of beginning the study
  • Pregnancy and women not on contraceptives

研究组 & 干预措施

Protein level 1

Experimental

干预措施: Dietary Protein Intake (Other)

Protein level 2

Experimental

干预措施: Dietary Protein Intake (Other)

Protein level 3

Experimental

干预措施: Dietary Protein Intake (Other)

结局指标

主要结局

Change from weight maintenance in muscle metabolism after energy restriction

时间窗: Measured after a 3 week energy deficit

次要结局

  • Change from weight maintenance in bone metabolism after energy restriction(Measured after a 3 week energy deficit)

研究者

发起方
United States Army Research Institute of Environmental Medicine
申办方类型
Fed
责任方
Sponsor

研究点 (2)

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