The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Difference in complements or peripheral blood mononuclear cells between CoViD-19 patients and controls
研究概览
简要总结
The current study is an open, non-randomized, monocentric, and interventional study. CoViD-19 patients will be recruited at UZ Brussel after informed consent is obtained. Whole blood and serum samples will be collected during acute disease (inclusion and 7 days after inclusion) and during patient follow-up at 2 months after infection.
Sample storage and subsequent use in fundamental research will be performed at VUB Neuro-Aging and Viro-Immunotherapy.
Additionally, medical records of UZ Brussel will be searched and epidemiological, clinical, radiological, and biological data of the selected patients will be obtained at the diagnosis time point and during follow-up.
Healthy volunteers will be recruited as well in the current study, as a comparison arm, after informed consent is obtained.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Positive nasopharyngeal reverse transcriptase-polymerase chain reaction for SARS-Coronavirus-02
- •Signed inform consent
- •Healthy Volunteers
- •Inclusion Criteria:
- •Signed inform consent
排除标准
- 未提供
研究组 & 干预措施
Controle
Whole blood and serum samples will be collected during the same period
干预措施: Blood analysis (Other)
Covid-19 patients
Whole blood and serum samples will be collected during acute disease (inclusion and 7 days after inclusion) and during patient follow-up at 2 months after infection
干预措施: Blood analysis (Other)
结局指标
主要结局
Difference in complements or peripheral blood mononuclear cells between CoViD-19 patients and controls
时间窗: up to 1 year
次要结局
未报告次要终点