Post-natal Depression and Chronic Stress

Completed

• Conditions: Depression, Postpartum

• Registration Number: NCT03088319
• Lead Sponsor: Institut de Recherche Biomedicale des Armees

Brief Summary

The risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The PND appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies.

This study aim to follow a cohort of pregnant women to determine the predictive psychobiological factors of the emergence of postnatal depression

Detailed Description

The prevalence of postnatal depression is high in civilian settings (20%). In mechanistic terms, the risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The post natal depression appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies.

* On the one hand, the repetition of stressors during pregnancy corresponds to a natural chronic stress model of several months and thus allows to study the biological cost of responses to repeated stresses, and the adaptive mechanisms leading to From functional drift to psychic dysfunction.

* On the other hand, isolated vulnerability factors characterize a mirroring psychological profile of a Mindfulness type of functioning. Mindfulness or full consciousness has been described as a state of consciousness which results from intentionally, at the present moment, without judging the experience that unfolds moment by moment. This psychological resource has been associated with resilient or even resilient psychic functioning.

This study aim to follow a cohort of pregnant women from the first trimester of pregnancies to 2 months after the delivery to determine the predictive psychobiological factors of the emergence of postnatal depression

Study Timeline

• Study First Submitted: 2017-03-11
• Study First Submitted QC: 2017-03-22
• Study First Posted: 2017-03-23
• Study Start: 2017-04-11
• Status Verified: 2018-08
• Primary Completion: 2019-10-11
• Study Completion: 2019-10-11
• Last Update Submitted: 2020-02-10
• Last Update Posted: 2020-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Physiological pregnancy
• Follow-up of pregnancy in a participating maternity
• Female over 18 years
• Affiliated to a social security scheme

Exclusion Criteria

• Multiple pregnancy
• Psychiatric, neurological, or endocrine or autoimmune diseases
• Hormonal or psychotropic treatments

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
post natal depression	baseline at three 3 months of pregnancy and two months after labour delivery	change in Edimbourg Post-Partum Depression scale at two months after labour delivery

Secondary Outcome Measures

Name	Time	Method
allostatic load as a composite index including blood GABA, BDNF and 8iso-Prostaglandins and capillary cortisol + heart rate variability index	baseline at three 3 months of pregnancy and two months after labour delivery	change in allostatic load two months after labour delivery

Trial Locations

Locations (1)

Marion Trousselard; 🇫🇷 Brétigny-sur-Orge, Not In US/Canada, France