Effect of Intensive Blood Pressure Control on the Burden of Atrial Fibrillation in Patientswith Non-permanent Atrial Fibrillation – Feasibility study

Western Sydney Local Health District0 个研究点目标入组 60 人开始时间: 2019年2月11日最近更新: 2019年7月15日

适应症

试验速览

暂无简介。

•Patients with non-permanent AF:
•-Patients with paroxysmal AF (PAF) with AF burden greater than or equal to 1% or AF duration >10 minutes in the preceding 6 months identified either by:
•A 5-7 day Holter monitor
•An in-situ loop recorder (ILR)
•An intracardiac device (pacemaker [PPM] or implanted cardiac defibrillator [ICD])
•-Patients with an episode of persistent AF (PeAF) cardioverted to sinus rhythm in the last 12 months
•Adults greater than or equal to 18 years
•Continuous rhythm monitoring possible:
•-pre-existing ILR, PPM or ICD, or
•-Consent to having an ILR insertion
•A measure of Clinic SBP greater than or equal to 130 and/ or DBP greater than or equal to 80 mmHg documented on the electronic medical record in the last 6 months or by study staff
•With no intention to change antiarrhythmic therapy in the coming 1 year

•Hypertensive crisis by medical judgement
•Patients that are scheduled to have catheter ablation in the next 3 months
•Contraindication to irbesartan, amlodipine, indapamide or bisoprolol
•Women who are pregnant, breast feeding and/ or of childbearing potential and not using effective contraception throughout the study (pharmacological or barrier methods)
•Concomitant illness, physical impairment or mental condition which in the opinion of the study team/ primary care physician could interfere with the conduct of the study including outcome assessments
•Participation in a concurrent clinical trial of an investigational medical product which will interfere with blood pressure.
•Inability or unwillingness to provide written informed consent
•Medical illness with anticipated life expectancy < 3 months
•Responsible primary care or other responsible physician believes it is not appropriate to participate in the study or unable to complete the study procedures, e.g. secondary hypertension, resistant hypertension, some concomitant illness, physical impairment or mental condition which could interfere with the conduct of the study including outcome assessments.

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