NCT02812134
Unknown
Not Applicable
Impact of Oral Phosphorus Supplements on the 6-month Change in FGF23 Levels in Anorexic Adolescents Suffering From Undernutrition.
ConditionsMalnutrition
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Malnutrition
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- FGF23
- Last Updated
- 7 years ago
Overview
Brief Summary
Fibroblast growth factor 23 (FGF23) is a recently discovered phosphaturic hormone produced by osteocytes. It is involved in phosphate-calcium metabolism (via its phosphaturic action and inhibition of 1,25-OH vitamin D).
There are no published studies on the role of FGF23 in undernourished anorexic adolescents taking oral phosphorus supplements.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adolescents aged from 11 to 17
- •Follow-up or hospitalisation for anorexia
- •Overt undernutrition (clinical signs of undernutrition, body mass index and the Waterlow index)
- •Social security coverage
Exclusion Criteria
- •Known pre-existing renal disorders
- •Known constitutional disorders of phosphate-calcium metabolism
- •Adult patients, legal guardianship, incarceration
Outcomes
Primary Outcomes
FGF23
Time Frame: at inclusion and then once a month for 6 months.
Change in the FGF23 level (U/ml) with regard to the exogenous phosphorus intake (doses of Phosphoneuros®, expressed in mg/kg/day)
Study Sites (1)
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