EEG Characteristics and Postoperative Delirium

Completed

• Conditions: Postoperative Delirium; PSI; Frailty; Cognitive Function Abnormal
• Interventions: Behavioral: delirium

• Registration Number: NCT06102967
• Lead Sponsor: Zhuo Liu

Brief Summary

The goal of this \[type of study: observational study \] is to \[compare Energy differences in various bands of intraoperative electroencephalogram in elderly patients with postoperative delirium and non delirium.\] in \[describe participant population selected 69 patients who underwent laparoscopic radical surgery for colorectal cancer on a selective basis\]. The main question\[s\] it aims to answer are:

• \[Is there any difference in the spectral range of EEG between POD patients and non POD patients\] Participants will \[Cognitive.•Postoperative delirium.•Preoperative weakness.\]

Detailed Description

The goal of this \[type of study: observational study \] is to \[compare Correlation between EEG data and postoperative delirium in elderly patients undergoing colorectal cancer radical surgery under preoperative frailty monitoring.\] in \[describe participant population selected 69 patients who underwent laparoscopic radical surgery for colorectal cancer on a selective basis\]. The main question\[s\] it aims to answer are:

• \[Is there any difference in the spectral range of EEG between POD patients and non POD patients\] Participants will \[Sedline EEG monitoring electrodes were placed 1cm above the eyebrows on both sides of the patient and at the temples on both sides, and were continuously monitored from the start of anesthesia in the operating room until the end of the surgery.Pay close attention to the vital signs and wait for the patient to fully recover and the vital signs to basically return to the preoperative level before returning to the ward.•Assessment of cognitive function using the Mini Mental State Scale (MMSE) 1 day before surgery and 7 days after surgery.•Preoperative assessment of frailty using the frailty screening scale.•Assess delirium using the ICU Patient Ambiguity Assessment Form (CAM-ICU) 1 day, 2 days, 3 days, and 7 days after surgery.\].

Study Timeline

• Study Start: 2023-10-01
• Study First Submitted: 2023-10-09
• Study First Submitted QC: 2023-10-21
• Study First Posted: 2023-10-26
• Primary Completion: 2024-05-01
• Study Completion: 2024-07-01
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-22
• Last Update Posted: 2024-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• ASA I-III
• The preoperative Frailty Scale (FRAIL) assessed frailty
• The patient or his/her family is informed about the study and signs an informed consent form

Exclusion Criteria

• Serious insufficiency of heart, liver, kidney and other functions
• Those with a history of psychiatric or neurological illness, long-term use of psychotropic drug
• History of cerebrovascular disease, brain trauma, or surgery
• The patient was allergic to coupler or unable to place electrodes on the head
• The patient was unable to complete the scale assessment as required.Patients with severe attention to hearing impairment were unable to complete the interview
• The patient was diagnosed with delirium before surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Delirious group	delirium	Postoperative delirium occurs

Primary Outcome Measures

Name	Time	Method
The number of minutes of suppression assessed by visual analysis of the EEG	Throughout the operation	The burst suppression time was calculated by EEG visual analysis
EEG power of each band	During the procedure	Recording frontal lobe electroencephalogram using a sedline root monitor (Masimo, Crop)
Postoperative delirium	1 day, 2 days, 3 days, and 7 days after surgery	Assessing delirium using the ICU Patient Ambiguity Assessment Form (CAM-ICU)

Trial Locations

Locations (1)

The first hospital of Qinhuangdao; 🇨🇳 Qinhuangdao, Hebei, China