Comparison of the effectiveness of therapy bromopride,metoclopramide,e ondasetron Intramuscular for treatment of vomiting
Phase 4
Active, not recruiting
- Conditions
- Gastroenteritis and non-infectious colitis, unspecifiedK52.9
- Registration Number
- RBR-5ky3ks
- Lead Sponsor
- nião Brasileira de Educação e Assistência
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
children who have experienced two or more episodes of vomiting in the last 24 hours, aged 1 year to 12 years, both genders; medical indication for receiving intramuscular antiemetic; when the country or guardians agree with the inclusion of a dependent in the study
Exclusion Criteria
bromopride known allergy to metoclopramide and ondansetron; vomiting due to sedation, anesthesia or chemotherapy; teenagers pregnant and / or breastfeeding; heart disease, advanced renal disease, urinary tract infection, epilepsy, intestinal obstruction, appendicitis, meningitis and diabetes mellitus, malnutrition, pneumonia, brain tumor
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the efficacy of bromopride, metoclopramide and ondansetron in a single intramuscular dose for treatment of vomiting in children treated in an emergency pediátrica.<br><br>Comparando the vomiting termination rates verified by measuring the observation of the researcher and parents' reports from the observation one significant variation among the three drugs tested in the reduction of vomiting after use.;Assess the number of late adverse events after use of antiemetics, observed by family members in the household in 24 hours and recorded by the researchers.<br><br><br>To evaluate the oral acceptance of fluids after use of antiemetics and the comparison between the three drugs. Recorded and observed by researchers.
- Secondary Outcome Measures
Name Time Method Within 24 hours, the cessation of vomiting occurred in 67.8% with bromopride, 67.2% with metoclopramide and 96.6% with ondansetron (p = 0.002).<br><br>;We compared the episodes of diarrhea before medicating (p = 0.039) and after doctoring (p = 0.183) for evaluating whether the drugs caused an increase of diarrhea. It was found that there was no increase in diarrhea, however, children decreased the number of evacuations after medicating.;Ondansetron group accepted best oral liquids, 200 ml, compared to bromopride, 150 ml and metoclopramide, 100 ml (p = 0.034).; Ondansetron was effective in the first hour and also in the next 6 h. No known side effects, had better success of oral rehydration, intravenous hydration and avoided hospitalization. The bromopride and metoclopramide were considered effective, but cause drowsiness which can increase the time of observation and hospital costs.