The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 144
- 试验地点
- 1
- 主要终点
- the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia
研究概览
简要总结
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
详细描述
the purpose of this study:(1) to investigate the incidence of preoperative cerebral oxygenation abnormity (SjvO2 <55%) and its relationship with intraoperative cerebral desaturation and POCD. (2) To investigate the change of intraoperative cerebral oxygen supply and demand balance and the incidence of cerebral desaturation in patients with abnormal preoperative cerebral oxygenation during sevoflurane anesthesia. (3)To investigate the incidence of early POCD in patients with abnormal preoperative cerebral oxygenation during sevoflurane and propofol anesthesia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less
排除标准
- •have a diagnosis of cerebrovascular disorder
结局指标
主要结局
the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia
时间窗: baseline ,every hour in the operation period,after extubation
SjvO2 were measured before anesthesia, after intubation, every hour during operation, after extubation by jugular vein blood and atrial blood gas analysis.The incidence of intraoperative cerebral desaturation was recorded when SjvO2\<50%.
次要结局
- the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia(1-3days、5-7days after operation)
- the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia(before anesthesia, after extubation ,1day after operation)
- the Change in the Level of Serum s-100β Between Propofol and Sevoflurane Anesthesia(before anesthesia,after extubation,1 day after operation)
研究者
Jun-ying Guo
Attending physician
First Affiliated Hospital, Sun Yat-Sen University