The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebral Hypoxia
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Enrollment
- 144
- Locations
- 1
- Primary Endpoint
- the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
Detailed Description
the purpose of this study:(1) to investigate the incidence of preoperative cerebral oxygenation abnormity (SjvO2 \<55%) and its relationship with intraoperative cerebral desaturation and POCD. (2) To investigate the change of intraoperative cerebral oxygen supply and demand balance and the incidence of cerebral desaturation in patients with abnormal preoperative cerebral oxygenation during sevoflurane anesthesia. (3)To investigate the incidence of early POCD in patients with abnormal preoperative cerebral oxygenation during sevoflurane and propofol anesthesia.
Investigators
Jun-ying Guo
Attending physician
First Affiliated Hospital, Sun Yat-Sen University
Eligibility Criteria
Inclusion Criteria
- •scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less
Exclusion Criteria
- •have a diagnosis of cerebrovascular disorder
Outcomes
Primary Outcomes
the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia
Time Frame: baseline ,every hour in the operation period,after extubation
SjvO2 were measured before anesthesia, after intubation, every hour during operation, after extubation by jugular vein blood and atrial blood gas analysis.The incidence of intraoperative cerebral desaturation was recorded when SjvO2\<50%.
Secondary Outcomes
- the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia(1-3days、5-7days after operation)
- the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia(before anesthesia, after extubation ,1day after operation)
- the Change in the Level of Serum s-100β Between Propofol and Sevoflurane Anesthesia(before anesthesia,after extubation,1 day after operation)