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临床试验/NCT05476731
NCT05476731Unknown不适用

Phenotypic and Genotypic Characterization of Malassezia Species Isolated From Malassezia Associated Skin Diseases

Sohag University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2022年8月最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
试验地点
1
主要终点
frequency of malassezia in patients

研究概览

简要总结

Genus Malassezia includes 14 species, namely M. furfur, M. sympodialis, M. globosa, M. restricta, M. slooffiae, M. obtusa, M. dermatis, M. japonica and M. yamatoensis associated with normal human flora but can also cause skin lesions, and M. pachydermatis, M. nana, M. equina, M. caprae and M. cuniculiare associated with animals. Few studies found that M. pachydermatis may be transmitted to humans from pets. M. pachydermmatis is the only lipid independent species while others are lipid dependent .

As Malassezia species have similar morphological and biochemical features, the currently used phenotypic techniques for diagnosis of Pityriasis versicolor usually do not allow rapid and exact characterization. In addition; they are time-consuming, multi-step processes requiring several experimental methods. Therefore, several molecular typing methods have been used successfully, resulting in identification and classification of new Malassezia species

Aim of the work:

  1. Phenotypic and Genotypic Characterization of Malassezia Species.
  2. Identify antifungal resistance pattern among isolated fungus.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

性别
All
接受健康志愿者

入选标准

  • Characteristic lesions of hypopigmented or hyperpigmented scaly macules and patches which may be associated with itching in patients with Pityriasis versicolor and scales of Seborrheic dermatitis and scales from patients with Atopic dermatitis.

排除标准

  • Patients with skin lesions of extensive desquamation or inflammation that do not match Pityriasis versicolor , Seborrheic dermatitis or Atopic dermatitis. Patients who had received topical antifungal therapy within last three months or oral antifungal therapy within the last six months

结局指标

主要结局

frequency of malassezia in patients

时间窗: 6 months

frequency of malassezia in patients with malassezia associated skin infection

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mai Mohamed Abozaid

Demonstrator of microbiology and immunology Faculty of Medicine_ SohagUniversity

Sohag University

研究点 (1)

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