Prognosis Factors in Patients With Primary Central Nervous System Lymphoma

• Conditions: PCNSL; Survival Analysis

• Registration Number: NCT05167630
• Lead Sponsor: Zhengzhou University

Brief Summary

Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-hodgkin's lymphoma confined to the central nervous system. It accounts for about 4% of all intracranial tumors and 4% to 6% of all non-Hodgkin's lymphomas . Among them, the most common type is diffuse large B cell lymphoma (DLBCL), accounting for about 95% of all cases. High dose methotrexate (HD-MTX) based chemotherapy can improve the prognosis of patients, but only 30% to 40% of patients can achieve sustained remission, and the overall prognosis is very poor\[4, 6\]. Currently, the International Extranodal Lymphoma Study Group (IESLG) prognostic scoring system and the Memorial Sloan Kettering Cancer Center (MSKCC) prognostic index are widely used to evaluate the prognosis in patients with PCNSL. However, IESLG model has some limitations such as the relatively small number of patients and short follow-up period. MSKCC model may have an inherent selection bias because retrospective data were collected from a single large institution. Therefore, there is a urgent need to identify novel indicators for prognosis evaluation and risk stratification in PCNSL patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-09-01
• Status Verified: 2021-12
• Study First Submitted: 2021-12-12
• Study First Submitted QC: 2021-12-12
• Last Update Submitted: 2021-12-12
• Primary Completion: 2021-12-15
• Study Completion: 2021-12-15
• Study First Posted: 2021-12-22
• Last Update Posted: 2021-12-22

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

(i)The pathological biopsy and immunohistochemistry diagnosis were PCNSL according to WHO diagnostic criteria for PCNSL in 2016. (ii) No treatment has been received. (iii)There were no diseases with malignant tumor, serious infection, other blood system diseases, immune system diseases and other conditions which may have great influence on peripheral blood lymphocyte count. (iv) The clinical data were complete.

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival	from September 1, 2013 to June 1, 2020	from the date of diagnosis to death from any cause or to the date of last follow-up

Trial Locations

Locations (1)

Zhengzhou university; 🇨🇳 Zhengzhou, Henan, China