Finger osteoArthritis Chondroitin Treatment Used in addition to Advice and Leaflets

Keele University0 sites380 target enrollmentNovember 18, 2016

Overview

No summary available.

Registry

who.int

Start Date

November 18, 2016

End Date

TBD

Last Updated

8 years ago

Study Type

Interventional

Sex

All

Sponsor

•1\. Aged 50 years and over
•2\. Fulfilling the American College of Rheumatology (ACR) definition of symptomatic hand OA
•3\. Hand pain \=4/10 NRS in at least one hand
•4\. Hand pain is present on some, most or all days in the past month
•5\. Able to have bilateral hand radiographs
•6\. Stable medicines/treatment regime for pain
•7\. Ability to understand and capable of giving written informed consent

•1\. Red flags e.g. history of serious illness or disease (e.g. stroke), progressive neurological signs, acute swollen joint; fractures or significant injury or surgery to the wrist or hand in the last 3 months
•2\. Inflammatory arthritis (e.g. rheumatoid arthritis, psoriatic arthritis)
•3\. Previous use of chondroitin sulphate – ever\*/within last 3 months (\*subject to internal pilot)
•4\. Recent (past 3 months) use of steroids (oral, intra\-muscular or intra\-articular)
•5\. Recent (past 3 months) use of glucosamine sulphate/hydrochloride
•6\. Recent (past 3 months) plain x\-rays of the hand(s)
•7\. Contra\-indications to the trial medication (significant hypersensitivity to the active ingredient or to any of the excipients; pregnancy or breastfeeding)
•8\. Isolated thumb base (carpometacarpal joint) OA
•9\. Severe comorbidities (severe liver disease, uncontrolled asthma, severe renal disease, congestive cardiac failure, malignancy, known clotting disorders, anticoagulants)
•10\. Vulnerable individuals (e.g. psychiatric illness, learning difficulties, dementia, terminal illness and severe enduring mental ill health)