5-AminoLevulinic Acid Aided Resection Margins in Sarcoma (5-ALARMS)
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Demonstrate the feasibility of 5-ALA aided fluorescent visualization of soft tissue sarcomas versus surrounding tissues
研究概览
简要总结
The goal of this study is to learn if the intervention using a fluorescent agent 5-Aminolevulinic acid (5-ALA) to aid in the surgical approach to visualize the soft-tissue sarcoma (STS) during surgical resection. 5-ALA goes through the blood stream and into the tumor tissue allowing it to light up when the surgeon uses a special light in the operating room. The technique is called 5-ALA fluorescence-guided surgery (FGS). The main question aims to answer if 5-ALA provide intraoperative fluorescent visualization of soft-tissue sarcoma versus surrounding tissue and demonstrate the efficacy of tumor and surgical margin resections by a gross and histological analysis of fluorescing and non-fluorescing samples immediately after removal. Participants will be asked to orally administer 5-ALA three to four hours prior to surgery in preoperative area.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological confirmation of any subtype of primary Grades 2 or 3 soft tissue sarcomas (STS), per biopsy evaluation by a pathologist, according to Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC).
- •Treatment decision includes planned surgical resection of STS.
- •Age ≥18 years at time of consent.
- •ECOG Performance Status 0 -
- •Hematology and blood chemistry parameters defined by:
- •Leukocytes ≥ 3 × 10(9)/L
- •Absolute neutrophil count ≥ 1.5 × 10(9)/L
- •Platelets ≥ 100 × 109/L, transfusions may be used to raise platelets to ≥ 100 × 10(9)/L (no washout required)
- •Hemoglobin ≥ 9 g/dL, transfusions may be used to raise Hgb to ≥ 9 g/dL (no washout required)
- •Total bilirubin ≤ 1.5 × institutional upper limit of normal (ULN)
- •Aspartate transaminase (AST) / alanine transaminase (ALT) ≤ 2.5 × institutional ULN
- •Creatinine within normal institutional limits OR creatinine clearance ≥ 30 mL/min/1.73 m2 for patients with creatinine above institutional ULN
- •Participants of reproductive potential must agree to using adequate contraception (e.g., hormonal or barrier method of birth control; abstinence, an intrauterine device) for the duration of study participation (including dosing interruptions) and up to 42 days after end of study intervention; or be surgically sterilized (e.g., hysterectomy, tubal ligation, or vasectomy).
- •Ability to swallow study agent.
- •Ability to understand and willingness to sign an informed consent form.
- •Ability and stated willingness to adhere to the study visit schedule and other protocol procedures/requirements for the duration of the study.
- •Inclusion of Minorities and Other Underrepresented Populations Recruitment is open and encouraged to all genders, all minorities, and underrepresented populations. Although distributions may vary by disease type, our recruitment procedures have been developed to enroll participants who are representative of the respective target population.
排除标准
- •Acute/chronic forms of porphyria.
- •Uncontrolled, known concurrent illness, including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness.
- •Patient has had chemotherapy, tumor resection, or radiation treatment ≤ 21 days prior to surgery.
- •Simultaneous participation in another clinical trial ≤ 21 days of enrollment or during the duration of the study period.
- •Planned use of other potentially phototoxic substances (e.g., St. John's wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides, quinolones and tetracyclines), and topical preparations containing aminolevulinic acid (5-ALA) for 24 hours during the perioperative period (defined as 24 hours prior to surgery to up to 24 hours post-surgery).
- •Pregnant or planning to become pregnant during study participation or breastfeeding.
- •Any condition that is in the opinion of the investigator would prohibit the understanding or rendering of informed consent or interfere with the participant's safety or compliance while on trial.
研究组 & 干预措施
Intervention Group
Patients diagnosed with Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) Grade 2 or 3 soft tissue sarcomas who undergo surgical resection will be administered 20 mg/kg body weight of 5-ALA orally at 3-4 hours prior to anesthesia.
干预措施: 5-ALA (Drug)
结局指标
主要结局
Demonstrate the feasibility of 5-ALA aided fluorescent visualization of soft tissue sarcomas versus surrounding tissues
时间窗: From enrollment to 2 weeks
Patients will receive 5-ALA administered in the preoperative area. Surgical resection of the soft tissue sarcoma will be done as per standard of care. A fluorescent headset will be turned on at defined time points below and tumor fluorescence will be noted (yes or no): 1. prior to skin incision 2. once dissection has reached fascial layer 3. when 50% of the tumor superficial-to-deep has been dissected 4. following complete resection of the tumor.
Surgeon survey results of intraoperative tumor fluorescence
时间窗: perioperative/periprocedural
Surgeons will fill out survey (yes or no) to answer following intraoperative assessment questions: 1. if the tumor demonstrated fluorescence from 5-ALA 2. Was the tumor fluorescence discernable from normal tissue. 3. Did the 5-ALA use increase or decrease the resection amount 4. Was the equipment was easy to use
次要结局
- Patient Reported Outcomes(From enrollment to 2 years)
- Demonstrate the efficacy of 5-ALA fluorescence in tumor resections by a histological analysis of fluorescing samples after tumor removal(Day of surgery)
- Patient Reported Outcomes(From enrollment to 2 years.)
- Demonstrate the efficacy of 5-ALA fluorescence in tumor resections by a histological analysis of non-fluorescing samples after tumor removal(Day of Surgery)
- Determine oncologic outcomes for patients enrolled(From enrollment to 2 years)