Comparing a targeted biopsy regimen with a targeted and surveillance (Seattle protocol) biopsy regimen in eradicated dysplastic Barrett's oesophagus: a prospective study

Not Applicable

Completed

• Conditions: Barrett's oesophagus; Oesophageal adenocarcinoma; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12618001198213
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-18
• Study Completion: 2020-12-31
• Last Update Posted: 15 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

Adult patients who have undergone successful Barrett's oesophagus eradication who are currently having follow-up surveillance endoscopies

Exclusion Criteria

patients with dysplastic Barrett's that have not achieved complete eradication of intestinal metaplasia.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of abnormal biopsies (findings other than neo-squamous epithelium; ie. intestinal metaplasia) found on targeted and surveillance biopsies as per Seattle protocol during upper endoscopy in previously eradicated dysplastic Barrett's oesophagus[At time of upper endoscopy]

Secondary Outcome Measures

Name	Time	Method
Time involved with obtaining endoscopic surveillance biopsies as per Seattle protocol. This will be measured using stopwatch timers. [At time of upper endoscopy];Cost involved with obtaining endoscopic surveillance biopsies as per Seattle protocol. The Seattle protocol biopsies are placed in a new specimen pot for each centimetre. The costs for the histological assessment are clearly defined for a single pot of biopsies therefore allowing an exact cost calculation. The costs will be obtained from the Pathology Queensland website (http://hsqapps.hsq.health.qld.gov.au/testlistPQ/default.aspx), which have the cost of various investigations available.[At time of upper endoscopy]