Bolus or continuous infusion if NTG in acute hypertensive heart failure

Phase 3

Recruiting

• Conditions: Circulatory System

• Registration Number: PACTR201905684437789
• Lead Sponsor: Cardiology department at Benha faculty of medicine in Benha University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-09-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. All adult patients presenting to the ED of either study site with hyper-tensive AHF.
2. The diagnosis of hypertensive AHF will be clinical and based on the presence of pulmonary rales, a portable chest radiograph determined by the treating physician to be consistent with pulmonary edema, and 1 or more of the following: a history of heart failure, tach-ypnea (respiratory rate [RR] > 30 breaths/min), significant dyspnea (use of accessory muscles of respiration or obvious air hunger), and significant hypoxia (defined as oxygen saturation [SpO2] < 90% on room air or < 95% on supplemental oxygen) or hypoxemia (partial pressure of arterial oxygen [PaO2] < 50 mm Hg on room air).
3. Ability to obtain written informed consent from the patient or a close family member.

Exclusion Criteria

Any of the following:
1. Noncardiogenic pulmonary edema, requirement for immediate intubation or cardiopulmonary resuscitation, 2. Inability to obtain informed consent because of alteration in cognition or consciousness or no family or alternative consenting source available
3. Known or suspected pregnancy
4. Acute ST-segment elevation myocardial infarction.
5. Suspected right-sided ventricular ischemia (ST segment depression or new T-wave inversions in leads V1 or V2)
6. Known sensitivity or intolerance to sublingual, transdermal, or intravenous nitroglycerin.

Study & Design

• Study Type: Interventional
• Study Design: Not specified