Bolus versus Continuous Infusion of Nitroglycerine for treatment of Acute hypertensive heart failure; a randomized clinical study

Cardiology department at Benha faculty of medicine in Benha University0 个研究点目标入组 200 人开始时间: 2018年9月27日最近更新: 2023年5月29日

试验速览

暂无简介。

•1. All adult patients presenting to the ED of either study site with hyper-tensive AHF.
•2. The diagnosis of hypertensive AHF will be clinical and based on the presence of pulmonary rales, a portable chest radiograph determined by the treating physician to be consistent with pulmonary edema, and 1 or more of the following: a history of heart failure, tach-ypnea (respiratory rate [RR] > 30 breaths/min), significant dyspnea (use of accessory muscles of respiration or obvious air hunger), and significant hypoxia (defined as oxygen saturation [SpO2] < 90% on room air or < 95% on supplemental oxygen) or hypoxemia (partial pressure of arterial oxygen [PaO2] < 50 mm Hg on room air).
•3. Ability to obtain written informed consent from the patient or a close family member.

•Any of the following:
•1. Noncardiogenic pulmonary edema, requirement for immediate intubation or cardiopulmonary resuscitation, 2. Inability to obtain informed consent because of alteration in cognition or consciousness or no family or alternative consenting source available
•3. Known or suspected pregnancy
•4. Acute ST-segment elevation myocardial infarction.
•5. Suspected right-sided ventricular ischemia (ST segment depression or new T-wave inversions in leads V1 or V2)
•6. Known sensitivity or intolerance to sublingual, transdermal, or intravenous nitroglycerin.

发起方

Cardiology department at Benha faculty of medicine in Benha University