Study of Omega-6 Fatty Acids in Patients With Hepatocellular Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Serum Omega-6 Fatty Acid Levels
研究概览
简要总结
This observational study investigates the association between serum Omega-6 fatty acids and hepatocellular carcinoma development. Adult HCC patients and age - and gender matched healthy controls will be included. Serum Omega-6 levels will be compared between groups to explore potential correlations with disease presence and severity .
详细描述
Hepatocellular carcinoma is a leading cause of cancer related deaths worldwide . Omega-6 fatty acids have been suggested to influence liver cancer development .This observational study aims to assess the association between serum Omega-6 fatty acid levels and HCC development .
Adult patients diagnosed with HCC will be recruited from Sohag University Hospital, along with age and gender matched healthy controls . Blood samples will be collected to measure serum Omega-6 levels using standardized bio-chemical assays . clinical and laboratory data , including liver function tests and tumor stage , will also be recorded.
The study will compare Omega-6 levels between HCC patients and controls , and analyze potential correlation with disease severity .Findings may provide insights into the role of Omega-6 fatty acids in HCC pathogenesis and help identify biomarkers for early detection and risk assessment .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1. Adults aged 18 years and above.
- •Patients with hepatocellular carcinoma (confirmed clinically, laboratory, radiologically, or histopathologically).
- •3. Ability and willingness to provide informed written consent.
- •For healthy controls: individuals without liver disease or history of malignancy, matched by age and gender.
- •5. For cirrhotic controls: patients with liver cirrhosis without evidence of any malignancy, matched by age and gender.
排除标准
- •History of chronic inflammatory (except for liver cirrhosis or HCC) or autoimmune diseases.
- •Current use of omega-6 or omega-3 fatty acid supplements.
- •Presence of other types of cancer.
- •Pregnant or lactating women.
- •presence of severe comorbid condition.
结局指标
主要结局
Serum Omega-6 Fatty Acid Levels
时间窗: At baseline
Measurement of circulating levels of Omega-6 fatty acids in blood samples of hepatocellular carcinoma patients and healthy controls using standardized laboratory techniques. The primary outcome will assess the association between serum Omega-6 concentrations and the presence of hepatocellular carcinoma.
次要结局
未报告次要终点
研究者
Mariam Maher Sobhy
Resident Doctor of Tropical Medicine and Gastro-enterology
Sohag University