Cohort Study on Characters and Distribution of Inherited Susceptible Genes Among Epithelial Ovarian Cancer Patients and Their Relatives in the North of China
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- herited gene mutations susceptible to epithelial ovarian cancer in patients and their relatives
研究概览
简要总结
Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china.
Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history.
Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china.
Enrollment: 1000
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •epithelial ovarian cancer and their relatves
- •living in the north of Huaihe River in China
- •being Han Chinese
排除标准
- •non-epithelial ovarian cancer
- •without specific pathological diagnosis
- •non-Han Chinese
结局指标
主要结局
herited gene mutations susceptible to epithelial ovarian cancer in patients and their relatives
时间窗: two years
次要结局
未报告次要终点
研究者
Lei Li
associate professor
Peking Union Medical College Hospital