Clinical profile of leprosy patient with neurological involvement and evaluation of cranial neuropathy using Advanced MRI sequences - A tertiary care centre based cross-sectional, observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 103
- 试验地点
- 1
研究概览
简要总结
Leprosy is a chronic infection caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. Neurological involvement is the most disabling aspect, resulting from Schwann cell invasion leading to inflammation, demyelination, and axonal loss, causing sensory, motor, and autonomic dysfunction with deformities. Emerging evidence challenges the traditional view that leprosy affects only peripheral nerves, showing involvement of the central and autonomic nervous systems. MRI studies have identified CNS lesions, particularly in brainstem regions associated with cranial nerve deficits.There is existing knowlege gap regarding the full specturum of neurological involvement in leprosy. The present study seek to analyse the neurological manifestation of leprosy through clinical evaluation and MRI findings in patients of leprosy with cranial neuropathy.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.All clinically confirmed cases of leprosy (as per WHO or Ridley–Jopling classification) including release from treatment.
- •2.Patients presenting with neurological symptoms or signs such as: Cranial nerve palsies, Peripheral neuropathy (sensory, motor, or mixed) and autonomic dysfunction.
- •3.Patients willing to participate and provide written informed consent.
排除标准
- •1.Age less than 18 years, and more than 60 years 2.Pregnant and lactating female 3.Patients with neuropathies attributable to other etiologies according to clinical experts (e.g., diabetes mellitus, alcoholism, nutritional deficiency, heavy metal toxicity, vasculitis).
- •4.Patients with contraindications to MRI (e.g., pacemaker, metallic implants, severe claustrophobia, high creatinine (1.2mg/dl).
- •5.Patients unwilling to participate.
研究者
Sushma Sharma
All India Institute of Medical Science Gorakhpur