A Comparison of the effects of amiodarone and osmolol in patients with septic shock

Phase 3

• Conditions: septic shock.; Sepsis, unspecified organism; A41.9

• Registration Number: IRCT20190929044923N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

septic shock receiving vasopressor despite adequate fluid therapy
Heart rate above 100 beats per minute for no apparent reason (such as fever, agitation, pain, anemia, and hypovolemia that should be treated before starting medication and hemodynamic tests)
Cardiac index above 2.5 liters / minute per square meter
Absence of arrhythmia

Exclusion Criteria

treatment with beta-blocker or amiodarone in the last 48 hours
Patient with heart valve problems
Pregnancy
Pulmonary fibrosis
Hypo / Hyperthyroidism
Known pulmonary hypertension
History of amiodarone intolerance
Post CPR conditions
Aortic aneurysm
ARDS with PaO2 / FiO2 less than 150

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stroke volume index. Timepoint: 0,6,12,24 hour after adminstration. Method of measurement: uscom.;Cardiac output index. Timepoint: 0 612 24 hours after adminstration. Method of measurement: uscom.;Heart rate. Timepoint: 0 6 12 24 hours after adminstration. Method of measurement: heart rate monitoring device.;Vascular resistance. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: uscom.;Acid lactic. Timepoint: baseline and 24hours after administration. Method of measurement: laboratory analysis.;Mean arterial pressure. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: monitoring device.;Vasopressor intake rate. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: View Cardex.;The amount of fluid received. Timepoint: baseline and 24hours after administration. Method of measurement: View Cardex.