Treatment of Complex Regional Pain Syndome type 1: a randomised, double-blind, placebo-controlled study with S(+)-ketamine.
Completed
- Conditions
- Complex Regional Pain Syndome type 1 (CRPS 1)
- Registration Number
- NL-OMON22578
- Lead Sponsor
- eiden University Medical Center, dep. Anaesthesiology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Patients will be male or female adult patients with a clinical diagnosis of CRPS 1 who are referred to the pain centre outpatients' clinic of the department of Anaesthesiology at the LUMC.
1. Patients should fulfill the diagnostic criteria of the consensus report of CRPS 1:
Exclusion Criteria
1. Patients who are not able to give informed consent.
2. Patients suffering from other pain syndromes, interfering with pain ratings.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Painreduction measured by numerical rating scale (0 no pain, 10 worst imaginable pain).
- Secondary Outcome Measures
Name Time Method Secondary aims of the study deal with:<br /><br>1. The role of NMDA receptor activation in the autonomic and motor features of CRPS; <br /><br>2. To establish the endurance of ketamine on the impairments of CRPS;<br /><br>3. To study the pharmacokinetics and pharmacodynamics of ketamine in subanaesthetic doses;<br /><br>4. To establish data for future pragmatic studies on ketamine i.v. in patients with CRPS on the levels of disability and safety.