Exploring the Relationship of Diets Inflammatory, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,220
- 试验地点
- 1
- 主要终点
- The prevalence of sarcopenia
研究概览
简要总结
Based on the analysis of dietary characteristics, gut microbiota diversity, and composition, this study investigates the relationships between the dietary inflammatory potential, gut microbiota, and sarcopenia. Furthermore, it explores the mediating role of gut microbiota in the association between the dietary inflammatory index and the risk of sarcopenia. The findings are expected to provide insights into the mechanisms through which dietary inflammation influences the development and progression of sarcopenia, and to offer a basis for dietary and nutritional interventions aimed at preventing or managing this condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Permanent residents of the community aged 60 years or older.
- •Continuous residence duration in the community for more than 5 years.
排除标准
- •Taking medications known to affect muscle function (e.g., corticosteroids, protein supplements, muscle enhancers).
- •Requiring walking assistance or having severe cognitive impairment that would preclude successful completion of assessments including bioelectrical impedance analysis (BIA), gait speed measurement, and handgrip strength testing.
- •Presence of a cardiac pacemaker, which contraindicates BIA measurement.
- •Diagnosis of one or more chronic diseases that significantly limit dietary intake.
结局指标
主要结局
The prevalence of sarcopenia
时间窗: Through study completion, an average of 1 year
The diagnosis of sarcopenia is confirmed according to the AWGS 2019 criteria, which requires the assessment of muscle strength, physical performance, and muscle mass.
Change in absolute abundance of Faecalibacterium prausnitzii
时间窗: Through study completion, an average of 1 year
16S rRNA absolute quantification was used to detect the microbial composition of the fecal samples.
Dietary Characteristics
时间窗: Through study completion, an average of 1 year
Dietary data were collected using a food frequency questionnaire (FFQ) to analyze dietary patterns and nutrient intake.
次要结局
未报告次要终点
研究者
Jianhua Ma
Lecturer
LanZhou University