Study of the Impact of Welding Fumes on the Arterial System : RISCAS Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Vascular reactivity
研究概览
简要总结
Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.
详细描述
In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or Female ≥ 18 years
- •Employee performing welding or airport operations
- •free, informed and written consent
- •Being affiliated to a social security system
排除标准
- •Taking cardiovascular medications which modify endothelial function and / or coagulation (antiplatelet, antihypertensive, cardiotropic).
- •People with a history of ischemic cardiovascular disease, thrombotic disease, chronic inflammatory disease
- •Pregnant women
- •People with health status would be likely, in the baseline state, to have parameters studied in the study disrupted.
结局指标
主要结局
Vascular reactivity
时间窗: 1 day
Assessement of microvascular reactivity by laser Doppler flowmetry associated to iontophoretic administration of ACh and SNP
次要结局
- vascular inflammation(1 day)
- Impregnation of metals activation(1 day)
- Coagulation activation(1 day)
- Oxidative stress activation(1 day)