Expression of hSPCA1 and ultrastructural analysis of the skin before and after laser therapy in Hailey-Hailey disease

Completed

• Conditions: acantholytic dermatosis; bullous dermatosis; 10040789

• Registration Number: NL-OMON56274
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Clinically diagnosed M. Hailey-Hailey as confirmed by histopathology and/or
genetic analysis.
- Indication for ablative laser therapy
- >18 years old
- Informed consent

Exclusion Criteria

- <18 years old
- Treatment with tetracyclines or oral retinoids within the last 30 days
preceding participation
- Lack of informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Expression of the hSPCA1 calcium pump in keratinocytes before and after<br /><br>ablative treatment. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Ultrastructure of the skin before and after ablative treatment.<br /><br>- Expression and localization of desmosomal proteins before and after ablative<br /><br>therapy.<br /><br>- Comparison of electron microscopy findings with those in subjects without M.<br /><br>Hailey-Hailey.</p><br>