Fluid Intake in Kidney Failure

Not Applicable

Completed

• Conditions: Chronic Renal Failure; Kidney Transplantation
• Interventions: Behavioral: high fluid intake; Behavioral: normal fluid intake

• Registration Number: NCT00842322
• Lead Sponsor: Medical University of Vienna

Brief Summary

Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation. In contrast,high fluid intake could be dangerous if urine excretion is reduced. In this study the researchers investigate whether increasing fluid intake from 2 to 4 litres per day has any influence on long-term renal outcome.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-02
• Study First Submitted: 2009-02-11
• Study First Submitted QC: 2009-02-11
• Study First Posted: 2009-02-12
• Last Update Submitted: 2009-02-12
• Last Update Posted: 2009-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Patients with native kidney disease or chronic kidney transplant failure
• An effective glomerular filtration rate (eGFR) according the MDRD formula between 20 and 75ml/min/1.73m2
• Ejection fraction >20%
• Absence of liver cirrhosis or ascites
• No evidence of active glomerulonephritis or immunosuppressive therapy if native kidney disease
• Acute transplant rejection
• Urinary protein excretion below 3g/d
• Age between 18 and 70 years.

Exclusion Criteria

• Therapy resistant edema
• Severe pulmonary disease
• Mean arterial pressure (MAP) > 120 mm Hg
• Pregnancy
• Kidney transplantation within three months prior to randomization

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High fluid intake	high fluid intake	fluid intake of 4 litres per day
normal fluid intake	normal fluid intake	Fluid intake of 2 litres per day

Trial Locations

Locations (1)

Medical University Vienna; 🇦🇹 Vienna, Austria