NCT00842322已完成不适用
The Effect of Increased Fluid Intake on Chronic Renal Failure
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 2
研究概览
简要总结
Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation. In contrast,high fluid intake could be dangerous if urine excretion is reduced. In this study the researchers investigate whether increasing fluid intake from 2 to 4 litres per day has any influence on long-term renal outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with native kidney disease or chronic kidney transplant failure
- •An effective glomerular filtration rate (eGFR) according the MDRD formula between 20 and 75ml/min/1.73m2
- •Ejection fraction >20%
- •Absence of liver cirrhosis or ascites
- •No evidence of active glomerulonephritis or immunosuppressive therapy if native kidney disease
- •Acute transplant rejection
- •Urinary protein excretion below 3g/d
- •Age between 18 and 70 years.
排除标准
- •Therapy resistant edema
- •Severe pulmonary disease
- •Mean arterial pressure (MAP) > 120 mm Hg
- •Pregnancy
- •Kidney transplantation within three months prior to randomization
研究者
研究点 (2)
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