The effect of trehalose on 28 and 60 days' all cause mortality and inflammatory and stress oxidative factors in critical ill stroke patients admitted to the intensive care unit (ICU): A double-blind randomized controlled clinical trial

Esfahan University of Medical Sciences0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年6月24日

试验速览

暂无简介。

•Willingness to cooperate and sign the consent form by the patient or the patient's legal guardian
•Diagnosis of stroke by a specialist doctor and hospitalization in the intensive care unit (ICU)
•Age 18 to 80 years
•Stable hemodynamic and metabolic conditions in the first 24 to 48 hours
•Having enteral nutrition
•Not having food intolerance to food sources containing trehalose such as mushrooms
•Glasgow Coma Scale (GCS) =3

•Having a history of cancer, autoimmune diseases, congenital metabolic diseases, underlying heart disease, kidney failure, liver failure and pancreatitis
•Patients who have cancer and are undergoing chemotherapy treatment.
•Pregnancy and breastfeeding.
•Impossibility of enteral nutrition in the first 48 hours of admission.
•Patients who are hospitalized in the intensive care unit for less than 48 hours.
•Patients undergoing dialysis.
•Patients who do not have an indication for enteral nutrition on the first day, and based on the diagnosis of the special care department, it is confirmed and predicted that they will not be able to receive enteral nutrition in the future. (nausea, persistent vomiting, ileus, intestinal obstruction, uncontrolled diarrhea (>500 mL/day), high-output fistula (>500 mL/day), intestinal inaccessibility, incomplete resuscitation, and hemodynamic instability.
•Patients who are under nutritional support by total intravenous nutrition.

发起方