Prospective cohort study on infections and their prophylaxis after splenectomy

• Conditions: D73.0; A41.9; Hyposplenism; Sepsis, unspecified

• Registration Number: DRKS00004332
• Lead Sponsor: niversitätsklinikum FreiburgCentrum für chronische Immundefizienz (CCI)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08-24
• Study Completion: 2019-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 459

Inclusion Criteria

Patients after splenectomy
no documented spleen on imaging studies
Hypo- or asplenia (Howell-Jolly-Bodies present)

Exclusion Criteria

no informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber and timing of infections requiring hospitalization after splenectomy

Secondary Outcome Measures

Name	Time	Method
•Number and timing of Infections requiring intensive care therapy after splenectomy<br>•Causal pathogen, focus of infection<br>•Total mortality and mortality due to infection after splenectomy <br>•Timing and type of required vaccination after splenectomy<br>•Antibiotic prophylaxis<br>•Concurrent or previous antineoplastic chemotherapy or immunosuppressive medication<br>•other risk factors for infection (age, sex, smoking, alcohol, body weight)