A Randomized Controlled Study on the Effect of S-Adenosyl Methionine Treatment on Anti-tumor Recurrence After Radical Treatment of Primary Hepatic Carcinoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 207
- 主要终点
- Time to tumor recurrence
研究概览
简要总结
The aim of this study is to explore the effect of SAMe on recurrence after radical treatment of Primary liver cancer.
详细描述
Primary liver cancer is now a major health problem. In the worldwide, PLC is the fifth most common cancer in male, the seventh in female, and has the second highest rate to cause death for men . Although the recent advances in treatment of Primary liver cancer have significantly improved the prognosis of patients with Primary liver cancer, the overall survival rate is still unsatisfactory. One of the reasons for the poor prognosis of Primary liver cancer is its high rate of recurrence. Anti-relapse treatment remains a pressing work to do.
In recent years, some study reported that SAMe had an impact on promoting apoptosis and inhibiting the growth on breast cancer, colon cancer, gastric cancer and liver cancer in vitro and vivo.
In this study, we aim to examine whether SAMe have an effect on improving patients' recurrence after radical treatment of Primary liver cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient must sign the informed consent prior to the beginning of any study-related procedures;
- •Patients diagnosed of Primary liver cancer;
- •BCLC Stage：Stage 0、Stage A;
- •Accept radical treatment;
排除标准
- •With any other anti-cancer treatment before or after the surgery;
- •Patients with extrahepatic metastasis;
- •Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction;
- •Subjects accepting other trial drugs or participating in other clinical trials;
- •Female with pregnancy or during the lactation period.
研究组 & 干预措施
S-Adenosyl Methionine Treatment
Patients will be treated with S-Adenosyl Methionine treatment after radical treatment.
2000mg, po
干预措施: S-Adenosyl Methionine (Drug)
结局指标
主要结局
Time to tumor recurrence
时间窗: 2 years
次要结局
- Overall survival(2 years)