Japanese Aortic Stenosis Study-2
Not Applicable
- Conditions
- patients with atrial fibrillation and warfarin usage, patients with cardiovascular diseases and without warfarin prescription
- Registration Number
- JPRN-UMIN000003007
- Lead Sponsor
- Tottori University
- Brief Summary
Despite higher atherosclerotic risks in the non-warfarin group, 2 or 3 newly calcified leaflets emerged during 4 years in 18.0% of patients in the warfarin group and in 6.9% in the non-warfarin group (p=0.014). Aortic valve area did not significantly change in the non-warfarin group during the follow-up, but tended to decrease in the warfarin group (p=0.057). Non-vitamin K antagonist oral anticoagulant got available in Japan after this study started, and warfarin was discontinued in 15 patients of the warfarin group. The reduction of aortic valve area was significant in the remaining 107 patients on the continuous warfarin treatment (p=0.002).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 600
Inclusion Criteria
Not provided
Exclusion Criteria
no
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method aortic valve calcification
- Secondary Outcome Measures
Name Time Method