The Effectiveness of Pentoxifylline and Colchicine in the Treatment of Covid-19

Phase 3

Recruiting

Conditions: covid 19.
COVID-19, virus identified
U07.1

Registration Number: IRCT20200721048159N3

Lead Sponsor: Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Hospitalized patients suspected to Covid19 infection
SpO2 less than 93%
The presence of respiratory symptoms (including shortness of breath, pain and pressure in the chest)
older than 40 years

Exclusion Criteria

Active peptic ulcer
Pregnancy and lactation
History of colchicine or pentoxifylline allergy
Concomitant use of protease inhibitors, strong inhibitors or inducers of CYP3A4 or pgp drugs, statin other than rosuvastatin
Occurrence of side effects
Fauvism
History of alcohol use
Retinopathy
Neuromuscular disease
Severe renal failure and GFR less than 30 ml/min
Severe hepatic impairment (bilirubin higher than 2 mg/dL and albumin less than 2.8 g/dL)
Active bleeding including intracerebral hemorrhage or retinal hemorrhage
Chronic diarrhea or malabsorption
History of heart disease (heart failure, ventricular arrhythmia, right or left heart block, QTc more than 480 milliseconds)
Dissatisfaction with the company

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of hospitalization. Timepoint: 7 -14 days. Method of measurement: Based on patient file information.

Secondary Outcome Measures

Name	Time	Method
The duration of recovery or the duration of entry into the disease stage. Timepoint: 7-14 days. Method of measurement: Based on patient file information.;Survival rate of 28 days from the time of hospitalization. Timepoint: 28 days after starting the study. Method of measurement: Interview with the patient or her family.;The amount of arterial oxygen saturation. Timepoint: Daily. Method of measurement: Using a device to measure the percentage of oxygen saturation.;Frequency of transfer to intensive care unit. Timepoint: Daily. Method of measurement: Under supervision.