Efficacy Of Platelet Rich Plasma (PRP) In Kellgren And Lawrence Grades 2-3 Osteoarthritis Of Knee Joint In Patients Attending a Tertiary Care Hospital In Kolkata.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
PROPOSED TOPIC OF RESEARCH:“EFFICACY OF PLATELET RICH PLASMA(PRP)IN KL GRADES 2-3
OSTEOARTHRITIS OF KNEE JOINT IN PATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN KOLKATA."
OBJECTIVES:To evaluate the efficacy of intra-articular Platelet-Rich Plasma (PRP)injection in reducing pain
and improving functional outcomes in patients with osteoarthritis KL Grade II-III of the knee joint using validated
scoring systems such as the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)&To evaluate the
duration of symptomatic relief (based on VAS Score)provided by a single PRP injection over a defined follow-up period for 1
year.To Standardised the Quantity,Dosing,Volume of PRP.
BACKGROUND OF PRESENT STUDY:
Osteoarthritis (OA)of the knee is a common degenerative joint disease and a major cause of disability among
the adult population worldwide.It is characterized by progressive loss of articular cartilage,synovial
inflammation,and changes in subchondral bone,leading to pain,stiffness,and decreased mobility[1].
Osteoarthritis,typically corresponding to Kellgren-Lawrence grade Il or III,provides a window for early
intervention before irreversible joint damage sets in[2].Platelet-Rich Plasma(PRP),an autologous bloodderived
product rich in growth factors,has gained attention for its potential to enhance cartilage repair and modulate
inflammation[3].Clinical studies have demonstrated that PRP may improve pain and function in early knee OA,
but inconsistent protocols Standardization and outcomes highlight the need for further research[4].
METHODOLOGY
This study will employ a Pre-Post Quasi Experiment design,analyzing data from patients diagnosed with
knee osteoarthritis (Kellgren-Lawrence grade II-III)who receive intra-articular PRP injections.Patient
demographics,including age,sex,body mass index (BMI),and physical activity level,will be recorded at
baseline.Baseline and follow-up assessments of pain,stiffness,and physical function will be conducted using
the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)&Visual Analog scale(VAS).
PRP preparation details,including volume,will also be documented.Statistical analyses will be performed to
evaluate changes in WOMAC scores over time and to determine associations between patient characteristics
and treatment outcomes,using paired t-tests and multiple regression analyses to identify significant
predictors of clinical improvement.
EXPECTED OUTCOME:The expected outcome of this study is that PRP injections will lead to a significant
improvement in pain relief,joint stiffness,and physical function as measured by WOMAC index and VAS
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Diagnosed with knee osteoarthritis (Kellgren-Lawrence grade II or lI)
- •Presence of chronic knee pain for at least 3 months 3.Able and willing to provide informed consent 4.Willing to undergo intra-articular PRP injection and adhere to follow-up protocol
- •Seronegative Adults
- •Patients with Unilateral or Bilateral knee oA of grades 2-3 (KL classification) ; For B/L OA, the more symptomatic knee (acc.
- •To VAS Score) will be selected, C/L knee must not have undergone PRP or intraarticular steroid injection in last 3 months.
排除标准
- •1.Advanced osteoarthritis (Kellgren-Lawrence grade 4) 2.History of inflammatory joint diseases (e.g., rheumatoid arthritis, gout) 3.Recent knee trauma or surgery within the past 6 months 4.Active joint infection or systemic infection.
研究者
Dr Yatharth Ranjan
RG Kar Medical College And Hospital