Impact of Neurally Adjusted Ventilator Assist (NAVA) Mode on Patient Ventilator Asynchrony Using Non-invasive Ventilation (NAVA-NIV)

Completed

• Conditions: Weaning Period

• Registration Number: NCT01280760
• Lead Sponsor: Pierre and Marie Curie University

Brief Summary

Non-invasive ventilation (NIV) has been proposed to reduce the incidence of ventilatory dysfunction following mechanical ventilation weaning. However, the nasogastric tube reduces the airtightness of the facial mask used to perform non-invasive ventilation and induces air leaks. The presence of leaks at the patient-mask interface can increase the risk of patient-ventilator asynchrony, which in turn leads to increase patient discomfort. Neurally adjusted ventilatory assist (NAVA)could contribute to decreasing asynchrony. Its principle is to record the diaphragmatic electrical activity and to control the ventilator. The investigators hypothesized driving the ventilator based on a neural signal (diaphragm electrical activity) would reduce patient-ventilator asynchronies in NIV

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-01-19
• Study First Submitted QC: 2011-01-19
• Study First Posted: 2011-01-21
• Primary Completion: 2011-03
• Study Completion: 2011-05
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-18
• Last Update Posted: 2013-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Patients with increased risk of post-extubation ventilatory dysfunction following invasive mechanical ventilation weaning.

Exclusion Criteria

• Contra-indication to non-invasive ventilation
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Triggering delay	Every inspiration, for 10 minutes	Duration between the onset of neural inspiration and the onset of insufflation

Secondary Outcome Measures

Name	Time	Method
Cycling off delay	Every inspiration, for 10 minutes	Delay between the end of neural inspiration and the end of insufflation

Trial Locations

Locations (1)

Groupe Hospitalier Pitié Salpétrière, Department of intensive care and pneumology; 🇫🇷 Paris, France