Effect of intravenous N-acetylcysteine on prevention of atrial fibrillation after Coronary Artery Bypass Graft surgery(CABG) .
- Conditions
- Atrial Fibrillation.Atrial fibrillation and flutter
- Registration Number
- IRCT2015040921669N1
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 150
Patient's willingness to participate in the study and getting informed consent from them; Non-emergency CABG surgery; Using cardiopulmonary bypass pump; No history of cardiac tachyarrhythmias before surgery (including AF); Having sinus rhythm; Hemodynamic stability (50 MAP> and heart rate between 50-110); and age between 35 and 75 years.
Exclusion criteria: Heart failure patients with ejection fraction (EF) less than 30%; History of COPD, Hyperthyroidism; Occurrence of postoperative MI; Need to pacemaker post-operatively; Re-operation for any reason; Previous history of heart surgery; Use of anti-arrhythmic drugs (with the exception of beta-blockers); Using Inotropic drugs more than the usual dose (epinephrine infusion more than 0.1 mcg / kg / min and dopamine and dobutamine infuson more than 10 mcg / kg / min)
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative Atrial Fibrillation. Timepoint: 72 hours after surgery and continued after discharge from the ICU. Method of measurement: By the senior nurse in open heart surgical intensive care unit prosperity and approved by the monitoring device by cardiologists.
- Secondary Outcome Measures
Name Time Method Serum hsCRP. Timepoint: Preoperative and postoperatively in the first and third day. Method of measurement: With Elisa method and using Vidas.