Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat

• Conditions: Functional Neural Connectivity
• Interventions: Device: MRI scans

• Registration Number: NCT02498158
• Lead Sponsor: Sheba Medical Center

Brief Summary

Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Detailed Description

20 healthy subjects that had already underwent Heat Tolerance Test (HTT) at the Heller Institute of Medical Research (Sheba Medical Center) will be recruited and divided into 2 groups: heat tolerant and heat intolerant (according to the HTT results). They will be asked to arrive to one experimental day at the imaging department in Sheba Medical Center and undergo anatomical and functional MRI scans.

Third group will consist of 10 existing brain scans (separated from personal details) of healthy males, at the same age range and who had never gone through heat injury.

Data will be analysed by fMRI expert in order to compare the functional neural connectivity at rest between the three groups.

Study Timeline

• Status Verified: 2015-07
• Study First Submitted: 2015-07-12
• Study First Submitted QC: 2015-07-14
• Study First Posted: 2015-07-15
• Last Update Submitted: 2015-07-19
• Last Update Posted: 2015-07-21
• Study Start: 2015-09
• Primary Completion: 2016-09
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• generally healthy subjects
• underwent heat injury in the past two months
• underwent Heat Tolerance Test at the Heller Institute of Medical research

Exclusion Criteria

• drug or alcohol use
• history of neurological disorders, mental retardation or head injury
• history or diagnosis of psychiatric disorders
• claustrophobia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
experimental protocol	MRI scans	Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.

Primary Outcome Measures

Name	Time	Method
functional neural connectivity	one day	MRI scans will be interpreted by fMRI expert and then compared between heat tolerant and intolerant subjects.

Trial Locations

Locations (1)

Sheba medical center; 🇮🇱 Tel-Hashomer, Ramat- Gan, Israel