rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction
- Conditions
- Executive Function DisorderFunctional Magnetic Resonance Imaging
- Interventions
- Device: pseudo repetitive transcranial magnetic stimulationDevice: repetitive transcranial magnetic stimulation
- Registration Number
- NCT05575583
- Lead Sponsor
- Xuzhou Central Hospital
- Brief Summary
Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).
- Detailed Description
This study intends to use neuroimaging methods to observe the correlation between neuroinflammation and brain network abnormalities in patients with POCD, and verify the repair effect of rTMS intervention on the pathological changes, so as to provide a theoretical basis for further optimizing the establishment of rTMS localization therapy model for POCD.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- Heart valve replacement.
- 45 to 75 years old.
- definite cerebral infarction.
- failure and decompensation of vital organs
- physical metal implants.
- severe neuropsychiatric disorders.
- less than 9 years of education.
- alcohol abuse.
- drug dependence.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group pseudo repetitive transcranial magnetic stimulation Subjects underwent repetitive transcranial magnetic stimulation for five consecutive days from day 2 to day 6 after surgery，but the machine does not turn on. Intervention group repetitive transcranial magnetic stimulation Subjects underwent repetitive transcranial magnetic stimulation for five consecutive days from day 2 to day 6 after surgery. The stimulation target area was the posterior cingulate gyrus, and the neuronavigation system was used to accurately locate the stimulation target in this project. Continuous theta short rapid pulse mode (cTBS) was used. CTBS mode consisted of a slave stimulus delivered every 0.2 seconds (5Hz), and each slave stimulus consisted of three bursts of 50Hz. A single stimulus lasts about 40 seconds and totals 600 pulses. Stimulation sessions are from 8 to 10 a.m. daily.
- Primary Outcome Measures
Name Time Method Trail making test Postoperative 1 week Trail Making test (TMT) was used to evaluate the set switching in executive function
Corsi Block test Postoperative 1 week The visuospatial working memory of executive function was assessed by the Corsi Block test
Stroop color words test(SCWT) Postoperative 1 week The Stroop Color Words test (SCWT) was used to evaluate the dominant inhibition in executive function
- Secondary Outcome Measures
Name Time Method Functional magnetic resonance brain network characteristics Postoperative 1 week The changes of brain network between intervention group and control group before and after operation were compared. Resting-state fMRI and task-state fMRI were evaluated.
Trial Locations
- Locations (1)
Xuzhou Central Hospital
🇨🇳Xuzhou, Jiangsu, China