Clinical Study of Repeated Transcranial Magnetic Stimulation in the Prevention and Treatment of Postoperative Executive Dysfunction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Executive Function Disorder
- Sponsor
- Xuzhou Central Hospital
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- Trail making test
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).
Detailed Description
This study intends to use neuroimaging methods to observe the correlation between neuroinflammation and brain network abnormalities in patients with POCD, and verify the repair effect of rTMS intervention on the pathological changes, so as to provide a theoretical basis for further optimizing the establishment of rTMS localization therapy model for POCD.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Heart valve replacement.
- •45 to 75 years old.
Exclusion Criteria
- •definite cerebral infarction.
- •failure and decompensation of vital organs
- •physical metal implants.
- •severe neuropsychiatric disorders.
- •less than 9 years of education.
- •alcohol abuse.
- •drug dependence.
Outcomes
Primary Outcomes
Trail making test
Time Frame: Postoperative 1 week
Trail Making test (TMT) was used to evaluate the set switching in executive function
Corsi Block test
Time Frame: Postoperative 1 week
The visuospatial working memory of executive function was assessed by the Corsi Block test
Stroop color words test(SCWT)
Time Frame: Postoperative 1 week
The Stroop Color Words test (SCWT) was used to evaluate the dominant inhibition in executive function
Secondary Outcomes
- Functional magnetic resonance brain network characteristics(Postoperative 1 week)