NCT04741295Unknown不适用
To Study the Effect of Low Molecular Weight Heparin on the Adenomyosis Patients'Outcome of in Vitro Fertilization-embryo Transplantation
Nanjing University1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2020年2月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Early spontaneous abortion rate
研究概览
简要总结
In assisted reproductive technology, adenomyosis patients are characterized by lower clinical pregnancy rate, lower implantation rate and higher abortion rate. The purpose of this study is to explore whether low molecular weight heparin can reduce the abortion rate of adenomyosis patients in frozen thawed embryo transfer cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The basal serum level of FSH was less than 10 IU / L
- •Diagnosed with adenomyosis by ultrasound
- •The first frozen thawed embryo transfer cycle, by hormone replacement protocol
- •Transfer at least one high quality frozen embryo;
- •Patients agreed to use low molecular weight heparin after FET, and they were able to sign informed consent in person.
排除标准
- •With abnormal karyotype;
- •Accompanied with other uterine diseases: intrauterine adhesion, intramural myoma, moderate to severe endometriosis, congenital uterine malformation, endometrial tuberculosis, thin endometrium < 8mm on the day of transformation, etc;
- •PCOS, RIF patients;
- •There are indications of conventional anticoagulation or antiplatelet therapy, such as antiphospholipid syndrome, autoimmune diseases, coagulation dysfunction, etc;
- •There were contraindications to hormone replacement therapy and low molecular weight heparin;
- •Participating in other clinical studies;
- •Unable to follow-up
研究组 & 干预措施
Low molecular weight heparin Group
Experimental
Adenomyosis patients in Low molecular weight heparin group have Low molecular weight heparin in addition to normal luteal progesterone support.
干预措施: Low molecular weight heparin (Drug)
结局指标
主要结局
Early spontaneous abortion rate
时间窗: Within three months after frozen embryo transfer
次要结局
未报告次要终点
研究者
Li-jun Ding
Professor
Nanjing University
研究点 (1)
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