Training caregivers to enhance early child neurodevelopment in the prevention of konzo disease from toxic cassava in the Democratic Republic of Congo
Phase 1
Recruiting
- Conditions
- Mental and Behavioural DisordersNervous System Diseases
- Registration Number
- PACTR201901631942297
- Lead Sponsor
- niversity of Kinshasa
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
All mother-child dyads with children aged 0-5 years
Dyads living in Kahemba (study site)
Informed consent to participate in the study
Exclusion Criteria
Children with infectious or somatic conditions that can affect early child cognitive development
Children with other neurological conditions that can affect early child cognitive development
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be changes in cassava cyanogenic content by the trainees and Urine thiocyanate level in the children in their MISC/WTM versus WTM only intervention households and enhance early child development and neurocognition of children in the 200 included households.
- Secondary Outcome Measures
Name Time Method eurodevelopmental and cognitive performance scores in the children using selected tools for neurocognitive assessments
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What neurodevelopmental pathways are targeted by caregiver training in konzo disease prevention from toxic cassava exposure?
How does caregiver training compare to standard-of-care interventions in reducing konzo-related cerebellar ataxia in DRC children?
Are there biomarkers associated with early detection of konzo disease in populations with chronic cyanogenic glycoside exposure?
What adverse events are reported in Phase I trials of non-pharmacological interventions for neurodevelopmental disorders in DRC?
Can combination approaches of caregiver education and cassava detoxification methods improve konzo prevention outcomes in the University of Kinshasa trial?